Caffeine Alternatives: Theacrine | Buzz Without the Crash- Thomas DeLauer

Caffeine Alternatives: Theacrine | Buzz Without the Crash- Thomas DeLauer



Caffeine Alternatives: Theacrine | Buzz Without the Crash- Thomas DeLauer… Get more bio hacks here:
What is Theacrine? Theacrine’s unique properties have some hailing it as the next breakout star of the supplement industry. Theacrine (trademarked Teacrine) is an alkaloid molecule that appears to work in a similar way to caffeine. It’s an alkaloid molecule – which simply means that it’s a naturally occurring substance derived from plant extracts. In its natural form, Theacrine is typically found in a traditional Chinese tea known as Camilla assamica, or as it’s more commonly known, Kucha.

How Does Theacrine Work? Researchers have determined that theacrine works in two primary ways: it facilitates adenosinergic neurotransmission and dopaminergic neurotransmission. That means that theacrine enhances physical energy by causing adenosine-signaling changes similar to caffeine (1)

Theacrine vs. Caffeine:
– Theacrine has shown early promise in recent studies

– It appears to offer effects similar to caffeine – but with less tolerance

– That means you can continue taking theacrine in small dosages to achieve the same effects over time

– Theacrine has energy boosting effects similar to caffeine without the jitters, crash, and habituation that often accompanies caffeine

While theacrine is very similar in molecular structure to caffeine, it is very different when it comes to actions: Tolerance to caffeine builds much more quickly than to theacrine. A caffeine tolerance can form in four to five days!

A recent study published in the journal Pharmalogical found that after seven days of Theacrine supplementation subjects showed no signs desensitization. Simply put, Theacrine users can expect the same level of high potency with nearly every dose, without experiencing a decrease in effectiveness over time.
– While people enjoy the energy boosting effects of caffeine, the substance is often associated with an unpleasant “crash” wherein energy fades and mood falls.
– Caffeine’s stimulating properties can also make it difficult to rest following a workout or to fall asleep.
– Theacrine’s unique mechanisms of action do not lead to the same energy and mood crash or cause the same difficulties falling asleep (1,2)

Additional Known Benefits: Mood Enhancing Effects-
– Dopamine is one of the primary neurotransmitters in the brain, and is responsible for controlling pleasure centers in the brain.
– Studies indicate that a single dose of Theacrine has the ability to elevate levels of dopamine in the brain.
– Additionally, further analysis showed that after seven days of Theacrine supplementation, the damaging effects of chronic stress and anxiety on the body are significantly reduced (3)

Improved Liver Function and Detoxification (Glutathione)
– Too much oxidative stress has been linked to a number of degenerative health conditions such as heart disease, cancer, and Alzheimer’s.
– In order to combat the potential hazards of excessive oxidation, our bodies are equipped with a number of potent antioxidant defense mechanisms – glutathione.
– Studies indicate that following 7 days of Theacrine supplementation subjects showed elevated levels of glutathione inside cells, which suggest that the liver receives a secondary benefit from supplementation (4)

1) Theacrine Review | Uses, Side Effects, and Benefits. (n.d.). Retrieved from

2) Low-dose oral caffeine induces a specific form of behavioral sensitization in rats. – PubMed – NCBI. (n.d.). Retrieved from

3) Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors. – PubMed – NCBI. (n.d.). Retrieved from

4) Theacrine, a purine alkaloid obtained from Camellia assamica var. kucha, attenuates restraint stress-provoked liver damage in mice. – PubMed – NCBI. (n.d.). Retrieved from

5) Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities. – PubMed – NCBI. (n.d.). Retrieved from

6) Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement, Caffeine, or Placebo by Young Men and Women. – PubMed – NCBI. (n.d.). Retrieved from


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